Symbol: Name: ID: |
RFWD2 ring finger and WD repeat domain 2 GFS:6492 |
Gene name: | RFWD2 |
Chromosome: | 1q25.1-q25.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ10416, COP1, RNF200 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1347046 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17440 | RefSeq IDs: | NM_001001740 |
Entrez Gene ID: | 64326 | Ensembl Gene ID: | ENSG00000143207 |
VEGA IDs: | OTTHUMG00000034986 | UniProt ID: | Q8NHY2 |
UCSC ID: | uc001gku.1 | OMIM ID: | 608067 |
Pubmed: | PMID10395541 | ||
CCDS IDs: | CCDSCCDS30944.1 CCDS CCDS44279.1 |
E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene.
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.
Products for RFWD2 gene
Catalog | Product Name | Application | Company |
GFS:E06492 | ring finger and WD repeat domain 2; ELISA kit | ELISA | n/a |
GFS:A06492 | ring finger and WD repeat domain 2; Anti | ANTIBODIES | n/a |
GFS:P06492 | ring finger and WD repeat domain 2; Protien | Protien | n/a |