Symbol: Name: ID: |
RNASEH2A ribonuclease H2, subunit A GFS:7366 |
Gene name: | RNASEH2A |
Chromosome: | 19p13.13 |
Previous Symbols: | |
Previous Names: | ribonuclease H2, large subunit, "Aicardi-Goutieres syndrome 4" |
Aliases: | RNASEHI, RNHIA, RNHL, AGS4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916974 | Rat Genome Database ID: | RGD:1307248 |
HGNC ID: | HGNC:18518 | RefSeq IDs: | NM_006397 |
Entrez Gene ID: | 10535 | Ensembl Gene ID: | ENSG00000104889 |
VEGA IDs: | UniProt ID: | O75792 | |
UCSC ID: | uc002mvg.1 | OMIM ID: | 606034 |
Pubmed: | PMID9789007 PMID 16845400 | ||
CCDS IDs: | CCDSCCDS12282.1 |
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
Function: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Products for RNASEH2A gene
Catalog | Product Name | Application | Company |
GFS:E07366 | ribonuclease H2, subunit A; ELISA kit | ELISA | n/a |
GFS:A07366 | ribonuclease H2, subunit A; Anti | ANTIBODIES | n/a |
GFS:P07366 | ribonuclease H2, subunit A; Protien | Protien | n/a |