Symbol: Name: ID: |
RTEL1 regulator of telomere elongation helicase 1 GFS:5023 |
Gene name: | RTEL1 |
Chromosome: | 20q13.3 |
Previous Symbols: | C20orf41 |
Previous Names: | chromosome 20 open reading frame 41 |
Aliases: | bK3184A7.3, NHL, DKFZP434C013, KIAA1088, RTEL |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2139369 | Rat Genome Database ID: | RGD:1306721 |
HGNC ID: | HGNC:15888 | RefSeq IDs: | NM_016434 |
Entrez Gene ID: | 51750 | Ensembl Gene ID: | ENSG00000026036 |
VEGA IDs: | OTTHUMG00000032992 | UniProt ID: | Q9NZ71 |
UCSC ID: | uc002yft.1 | OMIM ID: | 608833 |
Pubmed: | PMID10655513 PMID 15210109 | ||
CCDS IDs: | CCDSCCDS13530.2 CCDS CCDS13531.1 |
In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability and telomere length. This gene is the human ortholog of the mouse Rtel gene, so its protein product may play similar roles in humans. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), generates a non-coding transcript. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
Function: ATP-dependent DNA helicase required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by promoting the disassembly of D loop recombination intermediates. Also required to regulate telomere length; probably due to its anti-recombinase function.
Products for RTEL1 gene
Catalog | Product Name | Application | Company |
GFS:E05023 | regulator of telomere elongation helicase 1; ELISA kit | ELISA | n/a |
GFS:A05023 | regulator of telomere elongation helicase 1; Anti | ANTIBODIES | n/a |
GFS:P05023 | regulator of telomere elongation helicase 1; Protien | Protien | n/a |