Symbol: Name: ID: |
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 GFS:20 |
Gene name: | RIPK1 |
Chromosome: | 6p25.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | RIP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108212 | Rat Genome Database ID: | RGD:1310158 |
HGNC ID: | HGNC:10019 | RefSeq IDs: | NM_003804 |
Entrez Gene ID: | 8737 | Ensembl Gene ID: | ENSG00000137275 |
VEGA IDs: | OTTHUMG00000014134 | UniProt ID: | Q13546 |
UCSC ID: | uc003mux.2 | OMIM ID: | 603453 |
Pubmed: | PMID7538908 PMID 8612133 | ||
CCDS IDs: | CCDSCCDS4482.1 |
Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the \'Lys-63\'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 deubiquitinates \'Lys-63\'- polyubiquitin chains on RIPK1 and catalyzes the formation of \'Lys- 48\'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently to the termination of the TNF- or LPS-mediated activation of NF-kappa-B.
Products for RIPK1 gene
Catalog | Product Name | Application | Company |
GFS:E00020 | receptor (TNFRSF)-interacting serine-threonine kinase 1; ELISA kit | ELISA | n/a |
GFS:A00020 | receptor (TNFRSF)-interacting serine-threonine kinase 1; Anti | ANTIBODIES | n/a |
GFS:P00020 | receptor (TNFRSF)-interacting serine-threonine kinase 1; Protien | Protien | n/a |