Symbol: Name: ID: |
PUM1 pumilio homolog 1 (Drosophila) GFS:4239 |
Gene name: | PUM1 |
Chromosome: | 1p35.2 |
Previous Symbols: | |
Previous Names: | pumilio (Drosophila) homolog 1 |
Aliases: | PUMH1, KIAA0099 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1931749 | Rat Genome Database ID: | RGD:1307190 |
HGNC ID: | HGNC:14957 | RefSeq IDs: | NM_001020658 |
Entrez Gene ID: | 9698 | Ensembl Gene ID: | ENSG00000134644 |
VEGA IDs: | OTTHUMG00000003795 | UniProt ID: | Q14671 |
UCSC ID: | uc001bsh.1 | OMIM ID: | 607204 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS338.1 CCDS CCDS44099.1 |
Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene.
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
Products for PUM1 gene
Catalog | Product Name | Application | Company |
GFS:E04239 | pumilio homolog 1 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A04239 | pumilio homolog 1 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P04239 | pumilio homolog 1 (Drosophila); Protien | Protien | n/a |