| Symbol: Name: ID: |
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L GFS:5498 |
| Gene name: | PPM1L |
| Chromosome: | 3q26.1 |
| Previous Symbols: | |
| Previous Names: | protein phosphatase 1 (formerly 2C)-like |
| Aliases: | PP2CE |
| Name Aliases: | PP2Cepsilon, |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:2139740 | Rat Genome Database ID: | RGD:1305220 |
| HGNC ID: | HGNC:16381 | RefSeq IDs: | NM_139245 |
| Entrez Gene ID: | 151742 | Ensembl Gene ID: | ENSG00000163590 |
| VEGA IDs: | OTTHUMG00000159048 | UniProt ID: | Q5SGD2 |
| UCSC ID: | uc003fdr.2 | OMIM ID: | 611931 |
| Pubmed: | PMID12556533 | ||
| CCDS IDs: | CCDSCCDS33886.1 | ||
PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]).[supplied by OMIM, Apr 2008].
Function: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
Products for PPM1L gene
| Catalog | Product Name | Application | Company |
| GFS:E05498 | protein phosphatase, Mg2+/Mn2+ dependent, 1L; ELISA kit | ELISA | n/a |
| GFS:A05498 | protein phosphatase, Mg2+/Mn2+ dependent, 1L; Anti | ANTIBODIES | n/a |
| GFS:P05498 | protein phosphatase, Mg2+/Mn2+ dependent, 1L; Protien | Protien | n/a |
