| Symbol: Name: ID: |
PTGR1 prostaglandin reductase 1 GFS:7282 |
| Gene name: | PTGR1 |
| Chromosome: | 9q32 |
| Previous Symbols: | LTB4DH |
| Previous Names: | leukotriene B4 12-hydroxydehydrogenase |
| Aliases: | ZADH3 |
| Name Aliases: | zinc binding alcohol dehydrogenase domain containing 3 |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1914353 | Rat Genome Database ID: | RGD:621195 |
| HGNC ID: | HGNC:18429 | RefSeq IDs: | NM_001146108 |
| Entrez Gene ID: | 22949 | Ensembl Gene ID: | ENSG00000106853 |
| VEGA IDs: | OTTHUMG00000020493 | UniProt ID: | Q14914 |
| UCSC ID: | uc004bfh.2 | OMIM ID: | 601274 |
| Pubmed: | PMID8576264 PMID 17449869 | ||
| CCDS IDs: | CCDSCCDS6779.1 | ||
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].
Function: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
Products for PTGR1 gene
| Catalog | Product Name | Application | Company |
| GFS:E07282 | prostaglandin reductase 1; ELISA kit | ELISA | n/a |
| GFS:A07282 | prostaglandin reductase 1; Anti | ANTIBODIES | n/a |
| GFS:P07282 | prostaglandin reductase 1; Protien | Protien | n/a |
