Symbol: Name: ID: |
PROL1 proline rich, lacrimal 1 GFS:6361 |
Gene name: | PROL1 |
Chromosome: | 4q13.3 |
Previous Symbols: | |
Previous Names: | proline rich 1 |
Aliases: | BPLP, PRL1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107496 | Rat Genome Database ID: | RGD:620983 |
HGNC ID: | HGNC:17279 | RefSeq IDs: | NM_021225 |
Entrez Gene ID: | 58503 | Ensembl Gene ID: | ENSG00000171199 |
VEGA IDs: | UniProt ID: | Q99935 | |
UCSC ID: | uc003hfi.2 | OMIM ID: | 608936 |
Pubmed: | PMID8670737 | ||
CCDS IDs: | CCDSCCDS43235.1 |
This gene encodes a member of the proline-rich protein family. The protein may provide a protective function at the eye surface. [provided by RefSeq, Jul 2008].
Function: Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.
Products for PROL1 gene
Catalog | Product Name | Application | Company |
GFS:E06361 | proline rich, lacrimal 1; ELISA kit | ELISA | n/a |
GFS:A06361 | proline rich, lacrimal 1; Anti | ANTIBODIES | n/a |
GFS:P06361 | proline rich, lacrimal 1; Protien | Protien | n/a |