| Symbol: Name: ID: |
PRICKLE1 prickle homolog 1 (Drosophila) GFS:6111 |
| Gene name: | PRICKLE1 |
| Chromosome: | 12p11-q12 |
| Previous Symbols: | |
| Previous Names: | prickle-like 1 (Drosophila) |
| Aliases: | FLJ31937, EPM1B |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1916034 | Rat Genome Database ID: | RGD:735090 |
| HGNC ID: | HGNC:17019 | RefSeq IDs: | NM_001144881 |
| Entrez Gene ID: | 144165 | Ensembl Gene ID: | ENSG00000139174 |
| VEGA IDs: | UniProt ID: | Q96MT3 | |
| UCSC ID: | uc010skv.1 | OMIM ID: | 608500 |
| Pubmed: | PMID12525887 PMID 18976727 | ||
| CCDS IDs: | CCDSCCDS8742.1 | ||
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009].
Function: Necessary for nuclear localization of REST. May serve as nuclear receptor.
Products for PRICKLE1 gene
| Catalog | Product Name | Application | Company |
| GFS:E06111 | prickle homolog 1 (Drosophila); ELISA kit | ELISA | n/a |
| GFS:A06111 | prickle homolog 1 (Drosophila); Anti | ANTIBODIES | n/a |
| GFS:P06111 | prickle homolog 1 (Drosophila); Protien | Protien | n/a |
