Symbol: Name: ID: |
PUF60 poly-U binding splicing factor 60KDa GFS:6136 |
Gene name: | PUF60 |
Chromosome: | 8q24.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FIR, SIAHBP1, RoBPI |
Name Aliases: | siah binding protein 1, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915209 | Rat Genome Database ID: | RGD:621674 |
HGNC ID: | HGNC:17042 | RefSeq IDs: | NM_001136033 |
Entrez Gene ID: | 22827 | Ensembl Gene ID: | ENSG00000179950 |
VEGA IDs: | UniProt ID: | Q9UHX1 | |
UCSC ID: | uc003yzs.2 | OMIM ID: | 604819 |
Pubmed: | PMID10668799 PMID 10882074 PMID 17579712 | ||
CCDS IDs: | CCDSCCDS47933.1 CCDS CCDS47934.1 CCDS CCDS47935.1 |
Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene.
The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene. [provided by RefSeq, Jul 2008].
Function: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA
Products for PUF60 gene
Catalog | Product Name | Application | Company |
GFS:E06136 | poly-U binding splicing factor 60KDa; ELISA kit | ELISA | n/a |
GFS:A06136 | poly-U binding splicing factor 60KDa; Anti | ANTIBODIES | n/a |
GFS:P06136 | poly-U binding splicing factor 60KDa; Protien | Protien | n/a |