Symbol: Name: ID: |
PLK4 polo-like kinase 4 GFS:1280 |
Gene name: | PLK4 |
Chromosome: | 4q27-q28 |
Previous Symbols: | STK18 |
Previous Names: | serine/threonine kinase 18, "polo-like kinase 4 (Drosophila)" |
Aliases: | Sak |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:101783 | Rat Genome Database ID: | RGD:1305390 |
HGNC ID: | HGNC:11397 | RefSeq IDs: | NM_001190799 |
Entrez Gene ID: | 10733 | Ensembl Gene ID: | ENSG00000142731 |
VEGA IDs: | OTTHUMG00000133301 | UniProt ID: | O00444 |
UCSC ID: | uc003ifo.2 | OMIM ID: | 605031 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS3735.1 |
Serine/threonine-protein kinase PLK4 is an enzyme that in humans is encoded by the PLK4 gene. This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq].
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.
Products for PLK4 gene
Catalog | Product Name | Application | Company |
GFS:E01280 | polo-like kinase 4; ELISA kit | ELISA | n/a |
GFS:A01280 | polo-like kinase 4; Anti | ANTIBODIES | n/a |
GFS:P01280 | polo-like kinase 4; Protien | Protien | n/a |