Symbol: Name: ID: |
PVRL3 poliovirus receptor-related 3 GFS:6613 |
Gene name: | PVRL3 |
Chromosome: | 3q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | nectin-3, PPR3, PVRR3, DKFZP566B0846, CDw113, CD113 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1930171 | Rat Genome Database ID: | RGD:1309516 |
HGNC ID: | HGNC:17664 | RefSeq IDs: | NM_015480 |
Entrez Gene ID: | 25945 | Ensembl Gene ID: | ENSG00000177707 |
VEGA IDs: | OTTHUMG00000159239 | UniProt ID: | Q9NQS3 |
UCSC ID: | uc003dxt.1 | OMIM ID: | 607147 |
Pubmed: | PMID11024295 | ||
CCDS IDs: | CCDSCCDS2957.1 |
Poliovirus receptor-related 3 (nectin-3), also known as PVRL3 and CD113 (Cluster of Differentiation 113), is a human gene.
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Function: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Products for PVRL3 gene
Catalog | Product Name | Application | Company |
GFS:E06613 | poliovirus receptor-related 3; ELISA kit | ELISA | n/a |
GFS:A06613 | poliovirus receptor-related 3; Anti | ANTIBODIES | n/a |
GFS:P06613 | poliovirus receptor-related 3; Protien | Protien | n/a |