Symbol: Name: ID: |
PHIP pleckstrin homology domain interacting protein GFS:4841 |
Gene name: | PHIP |
Chromosome: | 6q14 |
Previous Symbols: | WDR11 |
Previous Names: | |
Aliases: | ndrp, FLJ20705, DCAF14 |
Name Aliases: | DDB1 and CUL4 associated factor 14 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1932404 | Rat Genome Database ID: | |
HGNC ID: | HGNC:15673 | RefSeq IDs: | NM_017934 |
Entrez Gene ID: | 55023 | Ensembl Gene ID: | ENSG00000146247 |
VEGA IDs: | OTTHUMG00000015071 | UniProt ID: | Q8WWQ0 |
UCSC ID: | uc003pir.2 | OMIM ID: | 612870 |
Pubmed: | PMID11018022 | ||
CCDS IDs: | CCDSCCDS4987.1 |
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Function: Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation.
Products for PHIP gene
Catalog | Product Name | Application | Company |
GFS:E04841 | pleckstrin homology domain interacting protein; ELISA kit | ELISA | n/a |
GFS:A04841 | pleckstrin homology domain interacting protein; Anti | ANTIBODIES | n/a |
GFS:P04841 | pleckstrin homology domain interacting protein; Protien | Protien | n/a |