Symbol: Name: ID: |
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 GFS:3685 |
Gene name: | PLEKHA1 |
Chromosome: | 10q26.3 |
Previous Symbols: | |
Previous Names: | pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 1 |
Aliases: | TAPP1 |
Name Aliases: | tandem PH domain containing protein-1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2442213 | Rat Genome Database ID: | RGD:1564153 |
HGNC ID: | HGNC:14335 | RefSeq IDs: | NM_001001974 |
Entrez Gene ID: | 59338 | Ensembl Gene ID: | ENSG00000107679 |
VEGA IDs: | OTTHUMG00000019184 | UniProt ID: | Q9HB21 |
UCSC ID: | uc001lge.1 | OMIM ID: | 607772 |
Pubmed: | PMID11001876 PMID 15485858 | ||
CCDS IDs: | CCDSCCDS7629.1 |
Pleckstrin homology domain-containing family A member 1 is a protein that in humans is encoded by the PLEKHA1 gene.
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010].
Function: Binds specifically to phosphatidylinositol-3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
Products for PLEKHA1 gene
Catalog | Product Name | Application | Company |
GFS:E03685 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; ELISA kit | ELISA | n/a |
GFS:A03685 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Anti | ANTIBODIES | n/a |
GFS:P03685 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Protien | Protien | n/a |