Symbol: Name: ID: |
PITRM1 pitrilysin metallopeptidase 1 GFS:6612 |
Gene name: | PITRM1 |
Chromosome: | 10p15.2 |
Previous Symbols: | |
Previous Names: | pitrilysin metalloproteinase 1 |
Aliases: | MP1, KIAA1104, hMP1, PreP |
Name Aliases: | PreP peptidasome |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916867 | Rat Genome Database ID: | RGD:1310998 |
HGNC ID: | HGNC:17663 | RefSeq IDs: | NM_014889 |
Entrez Gene ID: | 10531 | Ensembl Gene ID: | ENSG00000107959 |
VEGA IDs: | OTTHUMG00000017557 | UniProt ID: | Q5JRX3 |
UCSC ID: | uc001igt.1 | OMIM ID: | |
Pubmed: | PMID1036083 PMID 10470851 PMID 16849325 | ||
CCDS IDs: |
Presequence protease, mitochondrial is an enzyme that in humans is encoded by the PITRM1 gene.
Function: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
Products for PITRM1 gene
Catalog | Product Name | Application | Company |
GFS:E06612 | pitrilysin metallopeptidase 1; ELISA kit | ELISA | n/a |
GFS:A06612 | pitrilysin metallopeptidase 1; Anti | ANTIBODIES | n/a |
GFS:P06612 | pitrilysin metallopeptidase 1; Protien | Protien | n/a |