Symbol: Name: ID: |
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) GFS:5049 |
Gene name: | PLCB1 |
Chromosome: | 20p12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0581, PLC-I, PLC154 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:97613 | Rat Genome Database ID: | RGD:3344 |
HGNC ID: | HGNC:15917 | RefSeq IDs: | NM_015192 |
Entrez Gene ID: | 23236 | Ensembl Gene ID: | ENSG00000182621 |
VEGA IDs: | OTTHUMG00000031849 | UniProt ID: | Q9NQ66 |
UCSC ID: | uc002wnb.2 | OMIM ID: | 607120 |
Pubmed: | PMID10760467 PMID 11118617 | ||
CCDS IDs: | CCDSCCDS13102.1 CCDS CCDS13103.1 |
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Products for PLCB1 gene
Catalog | Product Name | Application | Company |
GFS:E05049 | phospholipase C, beta 1 (phosphoinositide-specific); ELISA kit | ELISA | n/a |
GFS:A05049 | phospholipase C, beta 1 (phosphoinositide-specific); Anti | ANTIBODIES | n/a |
GFS:P05049 | phospholipase C, beta 1 (phosphoinositide-specific); Protien | Protien | n/a |