Symbol: Name: ID: |
PICALM phosphatidylinositol binding clathrin assembly protein GFS:4720 |
Gene name: | PICALM |
Chromosome: | 11q14 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CALM, CLTH |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2385902 | Rat Genome Database ID: | RGD:621054 |
HGNC ID: | HGNC:15514 | RefSeq IDs: | NM_001008660 |
Entrez Gene ID: | 8301 | Ensembl Gene ID: | ENSG00000073921 |
VEGA IDs: | UniProt ID: | Q13492 | |
UCSC ID: | uc001pbm.2 | OMIM ID: | 603025 |
Pubmed: | PMID8643484 | ||
CCDS IDs: | CCDSCCDS8272.1 CCDS CCDS31653.1 |
Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
Function: Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
Products for PICALM gene
Catalog | Product Name | Application | Company |
GFS:E04720 | phosphatidylinositol binding clathrin assembly protein; ELISA kit | ELISA | n/a |
GFS:A04720 | phosphatidylinositol binding clathrin assembly protein; Anti | ANTIBODIES | n/a |
GFS:P04720 | phosphatidylinositol binding clathrin assembly protein; Protien | Protien | n/a |