Symbol: Name: ID: |
PXDN peroxidasin homolog (Drosophila) GFS:4246 |
Gene name: | PXDN |
Chromosome: | 2p25.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0230, PRG2, MG50, D2S448, D2S448E, PXN |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916925 | Rat Genome Database ID: | RGD:1560694 |
HGNC ID: | HGNC:14966 | RefSeq IDs: | NM_012293 |
Entrez Gene ID: | 7837 | Ensembl Gene ID: | ENSG00000130508 |
VEGA IDs: | OTTHUMG00000059697 | UniProt ID: | Q92626 |
UCSC ID: | uc002qxa.2 | OMIM ID: | 605158 |
Pubmed: | PMID10441517 PMID 9039502 | ||
CCDS IDs: | CCDSCCDS46221.1 |
Peroxidasin homolog is a protein that in humans is encoded by the PXDN gene.
Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.[supplied by OMIM, Jul 2009].
Function: Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.
Products for PXDN gene
Catalog | Product Name | Application | Company |
GFS:E04246 | peroxidasin homolog (Drosophila); ELISA kit | ELISA | n/a |
GFS:A04246 | peroxidasin homolog (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P04246 | peroxidasin homolog (Drosophila); Protien | Protien | n/a |