| Symbol: Name: ID: |
PAPPA2 pappalysin 2 GFS:3910 |
| Gene name: | PAPPA2 |
| Chromosome: | 1q23-q25 |
| Previous Symbols: | PLAC3 |
| Previous Names: | placenta-specific 3 |
| Aliases: | PAPPE, PAPP-A2 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:3051647 | Rat Genome Database ID: | |
| HGNC ID: | HGNC:14615 | RefSeq IDs: | NM_020318 |
| Entrez Gene ID: | 60676 | Ensembl Gene ID: | ENSG00000116183 |
| VEGA IDs: | OTTHUMG00000035025 | UniProt ID: | Q9BXP8 |
| UCSC ID: | uc001gkz.2 | OMIM ID: | |
| Pubmed: | PMID11018262 PMID 11264294 | ||
| CCDS IDs: | CCDSCCDS41438.1 CCDS CCDS41439.1 | ||
Pappalysin-2 is a protein that in humans is encoded by the PAPPA2 gene.
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
Function: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.
Products for PAPPA2 gene
| Catalog | Product Name | Application | Company |
| GFS:E03910 | pappalysin 2; ELISA kit | ELISA | n/a |
| GFS:A03910 | pappalysin 2; Anti | ANTIBODIES | n/a |
| GFS:P03910 | pappalysin 2; Protien | Protien | n/a |
