Symbol: Name: ID: |
PILRB paired immunoglobin-like type 2 receptor beta GFS:7170 |
Gene name: | PILRB |
Chromosome: | 7q22.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FDFACT1, FDFACT2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2450532 | Rat Genome Database ID: | |
HGNC ID: | HGNC:18297 | RefSeq IDs: | NM_178238 |
Entrez Gene ID: | 29990 | Ensembl Gene ID: | ENSG00000121716 |
VEGA IDs: | OTTHUMG00000155363 | UniProt ID: | Q9UKJ0 |
UCSC ID: | uc003uun.2 | OMIM ID: | 605342 |
Pubmed: | PMID10660620 | ||
CCDS IDs: | CCDSCCDS43622.1 |
Paired immunoglobulin-like type 2 receptor beta is a protein that in humans is encoded by the PILRB gene.
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner, and functions in the activating role. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known. [provided by RefSeq, Aug 2010].
Function: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
Products for PILRB gene
Catalog | Product Name | Application | Company |
GFS:E07170 | paired immunoglobin-like type 2 receptor beta; ELISA kit | ELISA | n/a |
GFS:A07170 | paired immunoglobin-like type 2 receptor beta; Anti | ANTIBODIES | n/a |
GFS:P07170 | paired immunoglobin-like type 2 receptor beta; Protien | Protien | n/a |