Symbol: Name: ID: |
OPN4 opsin 4 GFS:3778 |
Gene name: | OPN4 |
Chromosome: | 10q22 |
Previous Symbols: | |
Previous Names: | opsin 4 (melanopsin) |
Aliases: | MOP |
Name Aliases: | melanopsin |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1353425 | Rat Genome Database ID: | RGD:621701 |
HGNC ID: | HGNC:14449 | RefSeq IDs: | NM_001030015 |
Entrez Gene ID: | 94233 | Ensembl Gene ID: | ENSG00000122375 |
VEGA IDs: | OTTHUMG00000018654 | UniProt ID: | Q9UHM6 |
UCSC ID: | uc001kdp.2 | OMIM ID: | 606665 |
Pubmed: | PMID10632589 | ||
CCDS IDs: | CCDSCCDS7376.1 CCDS CCDS31237.1 |
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function: Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).
Products for OPN4 gene
Catalog | Product Name | Application | Company |
GFS:E03778 | opsin 4; ELISA kit | ELISA | n/a |
GFS:A03778 | opsin 4; Anti | ANTIBODIES | n/a |
GFS:P03778 | opsin 4; Protien | Protien | n/a |