Symbol: Name: ID: |
NDE1 nudE nuclear distribution gene E homolog 1 (A. nidulans) GFS:6580 |
Gene name: | NDE1 |
Chromosome: | 16p13.11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | NUDE, FLJ20101 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914453 | Rat Genome Database ID: | RGD:620038 |
HGNC ID: | HGNC:17619 | RefSeq IDs: | NM_001143979 |
Entrez Gene ID: | 54820 | Ensembl Gene ID: | ENSG00000072864 |
VEGA IDs: | OTTHUMG00000129885 | UniProt ID: | Q9NXR1 |
UCSC ID: | uc002dds.2 | OMIM ID: | 609449 |
Pubmed: | PMID10940388 PMID 12427674 | ||
CCDS IDs: | CCDSCCDS10564.1 |
Nuclear distribution protein nudE homolog 1 is a protein that in humans is encoded by the NDE1 gene.
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009].
Function: Required for centrosome duplication. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). Required for formation and function of the mitotic spindle.
Products for NDE1 gene
Catalog | Product Name | Application | Company |
GFS:E06580 | nudE nuclear distribution gene E homolog 1 (A. nidulans); ELISA kit | ELISA | n/a |
GFS:A06580 | nudE nuclear distribution gene E homolog 1 (A. nidulans); Anti | ANTIBODIES | n/a |
GFS:P06580 | nudE nuclear distribution gene E homolog 1 (A. nidulans); Protien | Protien | n/a |