Symbol: Name: ID: |
NOD1 nucleotide-binding oligomerization domain containing 1 GFS:5506 |
Gene name: | NOD1 |
Chromosome: | 7p15-p14 |
Previous Symbols: | CARD4 |
Previous Names: | caspase recruitment domain family, member 4 |
Aliases: | NLRC1, CLR7.1 |
Name Aliases: | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1341839 | Rat Genome Database ID: | RGD:1562269 |
HGNC ID: | HGNC:16390 | RefSeq IDs: | NM_006092 |
Entrez Gene ID: | 10392 | Ensembl Gene ID: | ENSG00000106100 |
VEGA IDs: | OTTHUMG00000023923 | UniProt ID: | Q9Y239 |
UCSC ID: | uc003tav.2 | OMIM ID: | 605980 |
Pubmed: | PMID10224040 PMID 10329646 | ||
CCDS IDs: | CCDSCCDS5427.1 |
Nucleotide-binding oligomerization domain-containing protein 1 is a protein that in humans is encoded by the NOD1 gene.
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB.
Products for NOD1 gene
Catalog | Product Name | Application | Company |
GFS:E05506 | nucleotide-binding oligomerization domain containing 1; ELISA kit | ELISA | n/a |
GFS:A05506 | nucleotide-binding oligomerization domain containing 1; Anti | ANTIBODIES | n/a |
GFS:P05506 | nucleotide-binding oligomerization domain containing 1; Protien | Protien | n/a |