Symbol: Name: ID: |
NCOA6 nuclear receptor coactivator 6 GFS:5067 |
Gene name: | NCOA6 |
Chromosome: | 20q11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0181, RAP250, ASC2, AIB3, PRIP, TRBP, NRC |
Name Aliases: | nuclear receptor coactivator RAP250, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929915 | Rat Genome Database ID: | RGD:620111 |
HGNC ID: | HGNC:15936 | RefSeq IDs: | NM_014071 |
Entrez Gene ID: | 23054 | Ensembl Gene ID: | ENSG00000198646 |
VEGA IDs: | OTTHUMG00000032311 | UniProt ID: | Q14686 |
UCSC ID: | uc002xaw.2 | OMIM ID: | 605299 |
Pubmed: | PMID8724849 PMID 8263591 | ||
CCDS IDs: | CCDSCCDS13241.1 |
Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011].
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Products for NCOA6 gene
Catalog | Product Name | Application | Company |
GFS:E05067 | nuclear receptor coactivator 6; ELISA kit | ELISA | n/a |
GFS:A05067 | nuclear receptor coactivator 6; Anti | ANTIBODIES | n/a |
GFS:P05067 | nuclear receptor coactivator 6; Protien | Protien | n/a |