Symbol: Name: ID: |
NISCH nischarin GFS:6903 |
Gene name: | NISCH |
Chromosome: | 3p21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0975, I-1, IRAS |
Name Aliases: | imidazoline receptor candidate, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1928323 | Rat Genome Database ID: | RGD:1306950 |
HGNC ID: | HGNC:18006 | RefSeq IDs: | NM_007184 |
Entrez Gene ID: | 11188 | Ensembl Gene ID: | ENSG00000010322 |
VEGA IDs: | OTTHUMG00000158571 | UniProt ID: | Q9Y2I1 |
UCSC ID: | uc003ded.3 | OMIM ID: | |
Pubmed: | PMID11912194 PMID 10882231 | ||
CCDS IDs: | CCDSCCDS33767.1 |
Nischarin is a protein that in humans is encoded by the NISCH gene.
Function: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
Products for NISCH gene
Catalog | Product Name | Application | Company |
GFS:E06903 | nischarin; ELISA kit | ELISA | n/a |
GFS:A06903 | nischarin; Anti | ANTIBODIES | n/a |
GFS:P06903 | nischarin; Protien | Protien | n/a |