Symbol: Name: ID: |
NUB1 negative regulator of ubiquitin-like proteins 1 GFS:6584 |
Gene name: | NUB1 |
Chromosome: | 7q36 |
Previous Symbols: | |
Previous Names: | |
Aliases: | BS4, NYREN18 |
Name Aliases: | NEDD8 ultimate buster-1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889001 | Rat Genome Database ID: | RGD:1359489 |
HGNC ID: | HGNC:17623 | RefSeq IDs: | NM_016118 |
Entrez Gene ID: | 51667 | Ensembl Gene ID: | ENSG00000013374 |
VEGA IDs: | OTTHUMG00000157365 | UniProt ID: | Q9Y5A7 |
UCSC ID: | uc003wjw.2 | OMIM ID: | 607981 |
Pubmed: | PMID10508479 PMID 11259415 | ||
CCDS IDs: | CCDSCCDS47751.1 |
NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene.
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Function: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
Products for NUB1 gene
Catalog | Product Name | Application | Company |
GFS:E06584 | negative regulator of ubiquitin-like proteins 1; ELISA kit | ELISA | n/a |
GFS:A06584 | negative regulator of ubiquitin-like proteins 1; Anti | ANTIBODIES | n/a |
GFS:P06584 | negative regulator of ubiquitin-like proteins 1; Protien | Protien | n/a |