Symbol: Name: ID: |
MORF4L1 mortality factor 4 like 1 GFS:6078 |
Gene name: | MORF4L1 |
Chromosome: | 15q25.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MRG15, MORFRG15, HsT17725, Eaf3, MEAF3 |
Name Aliases: | MORF-related gene on chromosome 15, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1096551 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16989 | RefSeq IDs: | NM_006791 |
Entrez Gene ID: | 10933 | Ensembl Gene ID: | ENSG00000185787 |
VEGA IDs: | OTTHUMG00000143865 | UniProt ID: | Q9UBU8 |
UCSC ID: | uc002bel.2 | OMIM ID: | 607303 |
Pubmed: | PMID8619474 PMID 9110174 | ||
CCDS IDs: | CCDSCCDS10307.1 CCDS CCDS32304.1 |
Mortality factor 4-like protein 1 is a protein that in humans is encoded by the MORF4L1 gene.
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
Products for MORF4L1 gene
Catalog | Product Name | Application | Company |
GFS:E06078 | mortality factor 4 like 1; ELISA kit | ELISA | n/a |
GFS:A06078 | mortality factor 4 like 1; Anti | ANTIBODIES | n/a |
GFS:P06078 | mortality factor 4 like 1; Protien | Protien | n/a |