Symbol: Name: ID: |
MOCS3 molybdenum cofactor synthesis 3 GFS:4914 |
Gene name: | MOCS3 |
Chromosome: | 20q13.13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | UBA4, dJ914P20.3 |
Name Aliases: | ubiquitin-like modifier activating enzyme 4, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916622 | Rat Genome Database ID: | RGD:1307044 |
HGNC ID: | HGNC:15765 | RefSeq IDs: | NM_014484 |
Entrez Gene ID: | 27304 | Ensembl Gene ID: | ENSG00000124217 |
VEGA IDs: | OTTHUMG00000032741 | UniProt ID: | O95396 |
UCSC ID: | uc002xvy.1 | OMIM ID: | 609277 |
Pubmed: | PMID15910006 | ||
CCDS IDs: | CCDSCCDS13435.1 |
Adenylyltransferase and sulfurtransferase MOCS3 is an enzyme that in humans is encoded by the MOCS3 gene.
Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Jul 2008].
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
Products for MOCS3 gene
Catalog | Product Name | Application | Company |
GFS:E04914 | molybdenum cofactor synthesis 3; ELISA kit | ELISA | n/a |
GFS:A04914 | molybdenum cofactor synthesis 3; Anti | ANTIBODIES | n/a |
GFS:P04914 | molybdenum cofactor synthesis 3; Protien | Protien | n/a |