Symbol: Name: ID: |
MAPKAP1 mitogen-activated protein kinase associated protein 1 GFS:7588 |
Gene name: | MAPKAP1 |
Chromosome: | 9q34.11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MGC2745, SIN1, MIP1 |
Name Aliases: | stress-activated protein kinase-interacting 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2444554 | Rat Genome Database ID: | RGD:1305363 |
HGNC ID: | HGNC:18752 | RefSeq IDs: | NM_001006617 |
Entrez Gene ID: | 79109 | Ensembl Gene ID: | ENSG00000119487 |
VEGA IDs: | OTTHUMG00000020683 | UniProt ID: | Q9BPZ7 |
UCSC ID: | uc004bpv.2 | OMIM ID: | 610558 |
Pubmed: | PMID15363842 | ||
CCDS IDs: | CCDSCCDS6864.1 CCDS CCDS35139.1 CCDS CCDS35140.1 CCDS CCDS35141.1 CCDS CCDS48020.1 |
Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008].
Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription.
Products for MAPKAP1 gene
Catalog | Product Name | Application | Company |
GFS:E07588 | mitogen-activated protein kinase associated protein 1; ELISA kit | ELISA | n/a |
GFS:A07588 | mitogen-activated protein kinase associated protein 1; Anti | ANTIBODIES | n/a |
GFS:P07588 | mitogen-activated protein kinase associated protein 1; Protien | Protien | n/a |