Symbol: Name: ID: |
MRPS12 mitochondrial ribosomal protein S12 GFS:331 |
Gene name: | MRPS12 |
Chromosome: | 19q13.1-q13.2 |
Previous Symbols: | RPMS12 |
Previous Names: | |
Aliases: | RPS12, RPSM12 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1346333 | Rat Genome Database ID: | RGD:1306221 |
HGNC ID: | HGNC:10380 | RefSeq IDs: | NM_021107 |
Entrez Gene ID: | 6183 | Ensembl Gene ID: | ENSG00000128626 |
VEGA IDs: | OTTHUMG00000071513 | UniProt ID: | O15235 |
UCSC ID: | uc002oke.2 | OMIM ID: | 603021 |
Pubmed: | PMID9545647 PMID 9790755 | ||
CCDS IDs: | CCDSCCDS12525.1 |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq].
Products for MRPS12 gene
Catalog | Product Name | Application | Company |
GFS:E00331 | mitochondrial ribosomal protein S12; ELISA kit | ELISA | n/a |
GFS:A00331 | mitochondrial ribosomal protein S12; Anti | ANTIBODIES | n/a |
GFS:P00331 | mitochondrial ribosomal protein S12; Protien | Protien | n/a |