Symbol: Name: ID: |
MRPL41 mitochondrial ribosomal protein L41 GFS:3818 |
Gene name: | MRPL41 |
Chromosome: | 9q34.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MRP-L27, RPML27, BMRP, PIG3, MRPL27 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1333816 | Rat Genome Database ID: | RGD:1310241 |
HGNC ID: | HGNC:14492 | RefSeq IDs: | NM_032477 |
Entrez Gene ID: | 64975 | Ensembl Gene ID: | ENSG00000182154 |
VEGA IDs: | OTTHUMG00000020987 | UniProt ID: | Q8IXM3 |
UCSC ID: | uc004cnh.3 | OMIM ID: | 611846 |
Pubmed: | PMID11543634 | ||
CCDS IDs: | CCDSCCDS7046.1 |
39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008].
Function: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
Products for MRPL41 gene
Catalog | Product Name | Application | Company |
GFS:E03818 | mitochondrial ribosomal protein L41; ELISA kit | ELISA | n/a |
GFS:A03818 | mitochondrial ribosomal protein L41; Anti | ANTIBODIES | n/a |
GFS:P03818 | mitochondrial ribosomal protein L41; Protien | Protien | n/a |