Symbol: Name: ID: |
MCM10 minichromosome maintenance complex component 10 GFS:6935 |
Gene name: | MCM10 |
Chromosome: | 10p13 |
Previous Symbols: | |
Previous Names: | MCM10 minichromosome maintenance deficient 10 (S. cerevisiae) |
Aliases: | PRO2249, CNA43, DNA43 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917274 | Rat Genome Database ID: | RGD:1311330 |
HGNC ID: | HGNC:18043 | RefSeq IDs: | NM_018518 |
Entrez Gene ID: | 55388 | Ensembl Gene ID: | ENSG00000065328 |
VEGA IDs: | OTTHUMG00000017694 | UniProt ID: | Q7L590 |
UCSC ID: | uc001ima.2 | OMIM ID: | 609357 |
Pubmed: | PMID11095689 PMID 17699597 | ||
CCDS IDs: | CCDSCCDS7095.1 CCDS CCDS7096.1 |
Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication.
Products for MCM10 gene
Catalog | Product Name | Application | Company |
GFS:E06935 | minichromosome maintenance complex component 10; ELISA kit | ELISA | n/a |
GFS:A06935 | minichromosome maintenance complex component 10; Anti | ANTIBODIES | n/a |
GFS:P06935 | minichromosome maintenance complex component 10; Protien | Protien | n/a |