Symbol: Name: ID: |
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 GFS:7770 |
Gene name: | MAGI2 |
Chromosome: | 7q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | AIP1, ARIP1, KIAA0705, ACVRIP1, MAGI-2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354953 | Rat Genome Database ID: | RGD:621855 |
HGNC ID: | HGNC:18957 | RefSeq IDs: | NM_012301 |
Entrez Gene ID: | 9863 | Ensembl Gene ID: | ENSG00000187391 |
VEGA IDs: | OTTHUMG00000130697 | UniProt ID: | Q86UL8 |
UCSC ID: | uc003ugx.2 | OMIM ID: | 606382 |
Pubmed: | PMID10681527 PMID 9734811 | ||
CCDS IDs: | CCDSCCDS5594.1 |
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.
Products for MAGI2 gene
Catalog | Product Name | Application | Company |
GFS:E07770 | membrane associated guanylate kinase, WW and PDZ domain containing 2; ELISA kit | ELISA | n/a |
GFS:A07770 | membrane associated guanylate kinase, WW and PDZ domain containing 2; Anti | ANTIBODIES | n/a |
GFS:P07770 | membrane associated guanylate kinase, WW and PDZ domain containing 2; Protien | Protien | n/a |