Symbol: Name: ID: |
MKL1 megakaryoblastic leukemia (translocation) 1 GFS:3684 |
Gene name: | MKL1 |
Chromosome: | 22q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1438, MAL, MRTF-A, BSAC |
Name Aliases: | megakaryocytic acute leukemia, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2384495 | Rat Genome Database ID: | RGD:1304873 |
HGNC ID: | HGNC:14334 | RefSeq IDs: | NM_020831 |
Entrez Gene ID: | 57591 | Ensembl Gene ID: | ENSG00000196588 |
VEGA IDs: | OTTHUMG00000151146 | UniProt ID: | Q969V6 |
UCSC ID: | uc003ayw.1 | OMIM ID: | 606078 |
Pubmed: | PMID11431691 PMID 12019265 PMID 14970199 | ||
CCDS IDs: | CCDSCCDS14003.1 |
MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity).
Products for MKL1 gene
Catalog | Product Name | Application | Company |
GFS:E03684 | megakaryoblastic leukemia (translocation) 1; ELISA kit | ELISA | n/a |
GFS:A03684 | megakaryoblastic leukemia (translocation) 1; Anti | ANTIBODIES | n/a |
GFS:P03684 | megakaryoblastic leukemia (translocation) 1; Protien | Protien | n/a |