Symbol: Name: ID: |
MAML1 mastermind-like 1 (Drosophila) GFS:3172 |
Gene name: | MAML1 |
Chromosome: | 5q35 |
Previous Symbols: | |
Previous Names: | mastermind (drosophila)-like 1 |
Aliases: | KIAA0200, Mam-1 |
Name Aliases: | mastermind homolog |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1890504 | Rat Genome Database ID: | RGD:1308631 |
HGNC ID: | HGNC:13632 | RefSeq IDs: | NM_014757 |
Entrez Gene ID: | 9794 | Ensembl Gene ID: | ENSG00000161021 |
VEGA IDs: | UniProt ID: | Q92585 | |
UCSC ID: | uc003mkm.2 | OMIM ID: | 605424 |
Pubmed: | PMID11101851 PMID 11390662 | ||
CCDS IDs: | CCDSCCDS34315.1 |
Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Products for MAML1 gene
Catalog | Product Name | Application | Company |
GFS:E03172 | mastermind-like 1 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A03172 | mastermind-like 1 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P03172 | mastermind-like 1 (Drosophila); Protien | Protien | n/a |