Symbol: Name: ID: |
MRC2 mannose receptor, C type 2 GFS:5961 |
Gene name: | MRC2 |
Chromosome: | 17q23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0709, ENDO180, CLEC13E, CD280 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107818 | Rat Genome Database ID: | RGD:1559436 |
HGNC ID: | HGNC:16875 | RefSeq IDs: | NM_006039 |
Entrez Gene ID: | 9902 | Ensembl Gene ID: | ENSG00000011028 |
VEGA IDs: | UniProt ID: | Q9UBG0 | |
UCSC ID: | uc002jad.2 | OMIM ID: | 612264 |
Pubmed: | PMID9734811 PMID 8702911 | ||
CCDS IDs: | CCDSCCDS11634.1 |
MRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007 [PubMed 17974964]).[supplied by OMIM, Sep 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).
Products for MRC2 gene
Catalog | Product Name | Application | Company |
GFS:E05961 | mannose receptor, C type 2; ELISA kit | ELISA | n/a |
GFS:A05961 | mannose receptor, C type 2; Anti | ANTIBODIES | n/a |
GFS:P05961 | mannose receptor, C type 2; Protien | Protien | n/a |