Symbol: Name: ID: |
MAEA macrophage erythroblast attacher GFS:3238 |
Gene name: | MAEA |
Chromosome: | 4p16.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | EMP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891748 | Rat Genome Database ID: | RGD:1309877 |
HGNC ID: | HGNC:13731 | RefSeq IDs: | NM_001017405 |
Entrez Gene ID: | 10296 | Ensembl Gene ID: | ENSG00000090316 |
VEGA IDs: | UniProt ID: | Q7L5Y9 | |
UCSC ID: | uc003gda.2 | OMIM ID: | 606801 |
Pubmed: | PMID9763581 | ||
CCDS IDs: | CCDSCCDS33936.1 CCDS CCDS33937.1 |
This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].
Function: Play a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
Products for MAEA gene
Catalog | Product Name | Application | Company |
GFS:E03238 | macrophage erythroblast attacher; ELISA kit | ELISA | n/a |
GFS:A03238 | macrophage erythroblast attacher; Anti | ANTIBODIES | n/a |
GFS:P03238 | macrophage erythroblast attacher; Protien | Protien | n/a |