Symbol: Name: ID: |
LIAS lipoic acid synthetase GFS:5540 |
Gene name: | LIAS |
Chromosome: | 4p14 |
Previous Symbols: | |
Previous Names: | |
Aliases: | LAS |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1934604 | Rat Genome Database ID: | RGD:1307270 |
HGNC ID: | HGNC:16429 | RefSeq IDs: | NM_006859 |
Entrez Gene ID: | 11019 | Ensembl Gene ID: | ENSG00000121897 |
VEGA IDs: | OTTHUMG00000099369 | UniProt ID: | O43766 |
UCSC ID: | uc003guf.2 | OMIM ID: | 607031 |
Pubmed: | PMID11124703 | ||
CCDS IDs: | CCDSCCDS3453.1 CCDS CCDS3454.1 |
The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
Function: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity).
Products for LIAS gene
Catalog | Product Name | Application | Company |
GFS:E05540 | lipoic acid synthetase; ELISA kit | ELISA | n/a |
GFS:A05540 | lipoic acid synthetase; Anti | ANTIBODIES | n/a |
GFS:P05540 | lipoic acid synthetase; Protien | Protien | n/a |