Symbol: Name: ID: |
LECT1 leukocyte cell derived chemotaxin 1 GFS:6097 |
Gene name: | LECT1 |
Chromosome: | 13q14.3 |
Previous Symbols: | MYETS1 |
Previous Names: | multiple myeloma tumor suppressor 1 |
Aliases: | CHM-I, CHM1, chondromodulin |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1341171 | Rat Genome Database ID: | RGD:620176 |
HGNC ID: | HGNC:17005 | RefSeq IDs: | NM_001011705 |
Entrez Gene ID: | 11061 | Ensembl Gene ID: | ENSG00000136110 |
VEGA IDs: | OTTHUMG00000016980 | UniProt ID: | O75829 |
UCSC ID: | uc001vhf.2 | OMIM ID: | 605147 |
Pubmed: | PMID9731231 PMID 10103018 | ||
CCDS IDs: | CCDSCCDS9437.1 CCDS CCDS45051.1 |
Chondromodulin-1 is a protein that in humans is encoded by the LECT1 gene.
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.
Products for LECT1 gene
Catalog | Product Name | Application | Company |
GFS:E06097 | leukocyte cell derived chemotaxin 1; ELISA kit | ELISA | n/a |
GFS:A06097 | leukocyte cell derived chemotaxin 1; Anti | ANTIBODIES | n/a |
GFS:P06097 | leukocyte cell derived chemotaxin 1; Protien | Protien | n/a |