Symbol: Name: ID: |
LZTS1 leucine zipper, putative tumor suppressor 1 GFS:3326 |
Gene name: | LZTS1 |
Chromosome: | 8p22 |
Previous Symbols: | |
Previous Names: | F37/Esophageal cancer-related gene-coding leucine-zipper motif |
Aliases: | FEZ1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2684762 | Rat Genome Database ID: | RGD:708565 |
HGNC ID: | HGNC:13861 | RefSeq IDs: | NM_021020 |
Entrez Gene ID: | 11178 | Ensembl Gene ID: | ENSG00000061337 |
VEGA IDs: | OTTHUMG00000097027 | UniProt ID: | Q9Y250 |
UCSC ID: | uc003wzr.2 | OMIM ID: | 606551 |
Pubmed: | PMID10097140 PMID 17349584 | ||
CCDS IDs: | CCDSCCDS6015.1 |
Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene.
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.
Products for LZTS1 gene
Catalog | Product Name | Application | Company |
GFS:E03326 | leucine zipper, putative tumor suppressor 1; ELISA kit | ELISA | n/a |
GFS:A03326 | leucine zipper, putative tumor suppressor 1; Anti | ANTIBODIES | n/a |
GFS:P03326 | leucine zipper, putative tumor suppressor 1; Protien | Protien | n/a |