Symbol: Name: ID: |
LRDD leucine-rich repeats and death domain containing GFS:5599 |
Gene name: | LRDD |
Chromosome: | 11p15.5 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PIDD, MGC16925, DKFZp434D229 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889507 | Rat Genome Database ID: | RGD:1311792 |
HGNC ID: | HGNC:16491 | RefSeq IDs: | NM_145886 |
Entrez Gene ID: | 55367 | Ensembl Gene ID: | ENSG00000177595 |
VEGA IDs: | OTTHUMG00000133306 | UniProt ID: | Q9HB75 |
UCSC ID: | uc001lro.1 | OMIM ID: | 605247 |
Pubmed: | PMID10825539 | ||
CCDS IDs: | CCDSCCDS7716.1 CCDS CCDS44508.1 |
Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010].
Function: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.
Products for LRDD gene
Catalog | Product Name | Application | Company |
GFS:E05599 | leucine-rich repeats and death domain containing; ELISA kit | ELISA | n/a |
GFS:A05599 | leucine-rich repeats and death domain containing; Anti | ANTIBODIES | n/a |
GFS:P05599 | leucine-rich repeats and death domain containing; Protien | Protien | n/a |