Symbol: Name: ID: |
LRRC8A leucine rich repeat containing 8 family, member A GFS:7829 |
Gene name: | LRRC8A |
Chromosome: | 9q34.2 |
Previous Symbols: | LRRC8 |
Previous Names: | leucine rich repeat containing 8 |
Aliases: | KIAA1437, FLJ10337 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2652847 | Rat Genome Database ID: | RGD:1311690 |
HGNC ID: | HGNC:19027 | RefSeq IDs: | NM_001127244 |
Entrez Gene ID: | 56262 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000020766 | UniProt ID: | Q8IWT6 |
UCSC ID: | uc010myp.2 | OMIM ID: | 608360 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS35155.1 |
Leucine-rich repeat-containing protein 8A is a protein that in humans is encoded by the LRRC8A gene.
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. (provided by RefSeq)
Function: Involved in B-cell development. Required for the pro-B cell to pre-B cell transition (By similarity).
Products for LRRC8A gene
Catalog | Product Name | Application | Company |
GFS:E07829 | leucine rich repeat containing 8 family, member A; ELISA kit | ELISA | n/a |
GFS:A07829 | leucine rich repeat containing 8 family, member A; Anti | ANTIBODIES | n/a |
GFS:P07829 | leucine rich repeat containing 8 family, member A; Protien | Protien | n/a |