Symbol: Name: ID: |
LPHN2 latrophilin 2 GFS:7426 |
Gene name: | LPHN2 |
Chromosome: | 1p31.1 |
Previous Symbols: | LPHH1 |
Previous Names: | latrophilin 1 |
Aliases: | KIAA0786, LEC1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2139714 | Rat Genome Database ID: | RGD:620835 |
HGNC ID: | HGNC:18582 | RefSeq IDs: | NM_012302 |
Entrez Gene ID: | 23266 | Ensembl Gene ID: | ENSG00000117114 |
VEGA IDs: | OTTHUMG00000009844 | UniProt ID: | O95490 |
UCSC ID: | uc001diu.2 | OMIM ID: | 607018 |
Pubmed: | PMID10760572 | ||
CCDS IDs: | CCDSCCDS689.1 |
Latrophilin-2 is a protein that in humans is encoded by the LPHN2 gene.
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined. [provided by RefSeq, Jul 2008].
Function: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity).
Products for LPHN2 gene
Catalog | Product Name | Application | Company |
GFS:E07426 | latrophilin 2; ELISA kit | ELISA | n/a |
GFS:A07426 | latrophilin 2; Anti | ANTIBODIES | n/a |
GFS:P07426 | latrophilin 2; Protien | Protien | n/a |