Symbol: Name: ID: |
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 GFS:4799 |
Gene name: | LAMTOR3 |
Chromosome: | 4q24-q26 |
Previous Symbols: | MAP2K1IP1, MAPKSP1 |
Previous Names: | mitogen-activated protein kinase kinase 1 interacting protein 1, "MAPK scaffold protein 1" |
Aliases: | MP1, MAPBP, Ragulator3 |
Name Aliases: | MEK partner 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929467 | Rat Genome Database ID: | |
HGNC ID: | HGNC:15606 | RefSeq IDs: | NM_021970 |
Entrez Gene ID: | 8649 | Ensembl Gene ID: | ENSG00000109270 |
VEGA IDs: | OTTHUMG00000131050 | UniProt ID: | Q9UHA4 |
UCSC ID: | uc003hvg.2 | OMIM ID: | 603296 |
Pubmed: | PMID9733512 PMID 15016825 | ||
CCDS IDs: | CCDSCCDS3652.1 |
Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene.
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011].
Function: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Products for LAMTOR3 gene
Catalog | Product Name | Application | Company |
GFS:E04799 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; ELISA kit | ELISA | n/a |
GFS:A04799 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; Anti | ANTIBODIES | n/a |
GFS:P04799 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; Protien | Protien | n/a |