Symbol: Name: ID: |
KIFAP3 kinesin-associated protein 3 GFS:6154 |
Gene name: | KIFAP3 |
Chromosome: | 1p36.13-q31.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SMAP, KAP3 |
Name Aliases: | Smg GDS |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107566 | Rat Genome Database ID: | RGD:1305191 |
HGNC ID: | HGNC:17060 | RefSeq IDs: | NM_001204514 |
Entrez Gene ID: | 22920 | Ensembl Gene ID: | ENSG00000075945 |
VEGA IDs: | OTTHUMG00000035947 | UniProt ID: | Q92845 |
UCSC ID: | uc001ggv.2 | OMIM ID: | 601836 |
Pubmed: | PMID8900189 | ||
CCDS IDs: | CCDSCCDS1288.1 |
Kinesin-associated protein 3 is a protein that in humans is encoded by the KIFAP3 gene.
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
Function: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).
Products for KIFAP3 gene
Catalog | Product Name | Application | Company |
GFS:E06154 | kinesin-associated protein 3; ELISA kit | ELISA | n/a |
GFS:A06154 | kinesin-associated protein 3; Anti | ANTIBODIES | n/a |
GFS:P06154 | kinesin-associated protein 3; Protien | Protien | n/a |