Symbol: Name: ID: |
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) GFS:3345 |
Gene name: | ITCH |
Chromosome: | 20q11.22 |
Previous Symbols: | |
Previous Names: | itchy (mouse homolog) E3 ubiquitin protein ligase |
Aliases: | AIP4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1202301 | Rat Genome Database ID: | RGD:1359556 |
HGNC ID: | HGNC:13890 | RefSeq IDs: | NM_031483 |
Entrez Gene ID: | 83737 | Ensembl Gene ID: | ENSG00000078747 |
VEGA IDs: | OTTHUMG00000032300 | UniProt ID: | Q96J02 |
UCSC ID: | uc002xak.2 | OMIM ID: | 606409 |
Pubmed: | PMID11318614 | ||
CCDS IDs: | CCDSCCDS13234.1 |
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for ITCH gene
Catalog | Product Name | Application | Company |
GFS:E03345 | itchy E3 ubiquitin protein ligase homolog (mouse); ELISA kit | ELISA | n/a |
GFS:A03345 | itchy E3 ubiquitin protein ligase homolog (mouse); Anti | ANTIBODIES | n/a |
GFS:P03345 | itchy E3 ubiquitin protein ligase homolog (mouse); Protien | Protien | n/a |