Symbol: Name: ID: |
IRX3 iroquois homeobox 3 GFS:3709 |
Gene name: | IRX3 |
Chromosome: | 16q12.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | IRX-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1197522 | Rat Genome Database ID: | RGD:1307424 |
HGNC ID: | HGNC:14360 | RefSeq IDs: | NM_024336 |
Entrez Gene ID: | 79191 | Ensembl Gene ID: | ENSG00000177508 |
VEGA IDs: | OTTHUMG00000133200 | UniProt ID: | P78415 |
UCSC ID: | uc002eht.1 | OMIM ID: | 612985 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS10750.1 |
IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009].
Function: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity).
Products for IRX3 gene
Catalog | Product Name | Application | Company |
GFS:E03709 | iroquois homeobox 3; ELISA kit | ELISA | n/a |
GFS:A03709 | iroquois homeobox 3; Anti | ANTIBODIES | n/a |
GFS:P03709 | iroquois homeobox 3; Protien | Protien | n/a |