Symbol: Name: ID: |
ILKAP integrin-linked kinase-associated serine/threonine phosphatase GFS:4761 |
Gene name: | ILKAP |
Chromosome: | 2q37.3 |
Previous Symbols: | |
Previous Names: | integrin-linked kinase-associated serine/threonine phosphatase 2C |
Aliases: | DKFZP434J2031, FLJ10181 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914694 | Rat Genome Database ID: | RGD:620128 |
HGNC ID: | HGNC:15566 | RefSeq IDs: | NM_030768 |
Entrez Gene ID: | 80895 | Ensembl Gene ID: | ENSG00000132323 |
VEGA IDs: | OTTHUMG00000133334 | UniProt ID: | Q9H0C8 |
UCSC ID: | uc002vxv.2 | OMIM ID: | |
Pubmed: | |||
CCDS IDs: | CCDSCCDS2526.1 |
Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008].
Function: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
Products for ILKAP gene
Catalog | Product Name | Application | Company |
GFS:E04761 | integrin-linked kinase-associated serine/threonine phosphatase; ELISA kit | ELISA | n/a |
GFS:A04761 | integrin-linked kinase-associated serine/threonine phosphatase; Anti | ANTIBODIES | n/a |
GFS:P04761 | integrin-linked kinase-associated serine/threonine phosphatase; Protien | Protien | n/a |