Symbol: Name: ID: |
INTS6 integrator complex subunit 6 GFS:4165 |
Gene name: | INTS6 |
Chromosome: | 13q14.3 |
Previous Symbols: | DDX26 |
Previous Names: | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 |
Aliases: | DICE1, HDB, Notchl2, DBI-1, DDX26A, INT6 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1202397 | Rat Genome Database ID: | RGD:1309480 |
HGNC ID: | HGNC:14879 | RefSeq IDs: | NM_001039937 |
Entrez Gene ID: | 26512 | Ensembl Gene ID: | ENSG00000102786 |
VEGA IDs: | OTTHUMG00000016945 | UniProt ID: | Q9UL03 |
UCSC ID: | uc001vfk.2 | OMIM ID: | 604331 |
Pubmed: | PMID10467397 PMID 16239144 | ||
CCDS IDs: | CCDSCCDS9428.1 CCDS CCDS41890.1 CCDS CCDS45048.1 |
Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.
Products for INTS6 gene
Catalog | Product Name | Application | Company |
GFS:E04165 | integrator complex subunit 6; ELISA kit | ELISA | n/a |
GFS:A04165 | integrator complex subunit 6; Anti | ANTIBODIES | n/a |
GFS:P04165 | integrator complex subunit 6; Protien | Protien | n/a |