| Symbol: Name: ID: |
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon GFS:3866 |
| Gene name: | IKBKE |
| Chromosome: | 1q31 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | IKKE, IKK-i, KIAA0151 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1929612 | Rat Genome Database ID: | RGD:1308352 |
| HGNC ID: | HGNC:14552 | RefSeq IDs: | NM_001193321 |
| Entrez Gene ID: | 9641 | Ensembl Gene ID: | ENSG00000143466 |
| VEGA IDs: | OTTHUMG00000036346 | UniProt ID: | Q14164 |
| UCSC ID: | uc001hdz.1 | OMIM ID: | 605048 |
| Pubmed: | PMID10421793 PMID 10882136 | ||
| CCDS IDs: | CCDSCCDS30996.1 | ||
Inhibitor of nuclear factor kappa-B kinase subunit epsilon is an enzyme that in humans is encoded by the IKBKE gene.
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009].
Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.
Products for IKBKE gene
| Catalog | Product Name | Application | Company |
| GFS:E03866 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; ELISA kit | ELISA | n/a |
| GFS:A03866 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; Anti | ANTIBODIES | n/a |
| GFS:P03866 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; Protien | Protien | n/a |
